In collaboration with IrsiCaixa, the Institut de Recerca de la Sida led by Dr. Bonaventura Clotet, the Fundació Glòria Soler has contributed to the advancement of HIV/AIDS research by supporting a therapeutic vaccine to treat HIV/AIDS and reduce the associated adverse effects. It has also contributed to research into the influences of the microbiome on the vaccine. The projects funded by the Gloria Soler Foundation in 2016 and 2017 were the HTI therapeutic vaccine and the BCN02 ROMI project.
The projects funded by the Gloria Soler Foundation have accompanied the design and development process of this molecule called HTI from the early laboratory stages to its arrival in the clinic. They have helped to find the formulation that allows the molecule to reach the desired areas, as well as the most effective combination of molecules. This includes studying the efficacy of combining the vaccine with the drug Romidepsin (BCN02 ROMI study), which is responsible for bringing HIV out of hiding so that it can be eliminated. This project led to the creation of a spin-off from Aelix therapeutics, recently acquired by Gilead, to sustain the research. The results of the project have been shared with the scientific community in articles published in high-impact journals such as Nature Medicine.
Today, thanks to advances in research, prevention and treatment, HIV is no longer a death sentence but a manageable chronic condition. People with HIV can live long and healthy lives.
Video from Fundació “la Caixa” – 2018
Treatment
Antiretroviral therapy (ART) has been a turning point in the history of HIV. This specific treatment blocks different processes of the virus, allowing full control of the infection and keeping the virus undetectable in the blood. This means that people with HIV whose virus is undetectable cannot transmit it, helping to reduce stigma and slow the spread of the pandemic. Although it currently requires daily dosing, advanced drugs are being developed that could be administered on a six-monthly basis. These treatments will not only significantly improve the quality of life of people with HIV and reduce the stigma associated with the disease, but also represent a paradigm shift in countries where adherence to treatment is a challenge. Global prevention efforts such as education, condom use and pre-exposure prophylaxis (PrEP) have reduced the rate of new infections. PrEP, a preventive antiretroviral treatment, has been shown to be 100% effective in preventing HIV. However, access is still limited and it is not available to all who need it.
In short, although the road is long, every day we are closer to defeating HIV, and with the combined efforts of the global community, we can look forward to a future free of this disease.
Documentation